Endocrine Abstracts

Introduction: Neutrophil/lymphocyte (N/L) ratio is considered as a sign of systemic inflammation in recent years. In our study, we aimed to investigate N/L ratio in hyperthyroid patients and healthy control group.Material & methods: A total of 121 hyperthyroid patients (71 patients with Graves’ disease and 50 patients with other causes of hyperthyroidism) and 40 healthy volunteers were enrolled. Complete blood count was obtained from both group ...

The notable expression of the androgen receptor (AR) in breast cancer suggests an important biological role and, hence, a window of utilizing it as a therapeutic target. Due to the undesirable side effects of AR agonists, attempts have been undertaken to develop tissue-selective androgen receptor modulators (SARMs). One such SARM is Cl-4AS-1, which has previously been shown to behave similar to the natural AR agonist, dihydrotestosterone (DHT). We aimed to examine the effects ...

MicroRNA molecules (miRNAs) have important roles in regulating cell behavior. In addition, their expression levels can be used in tumor classification. The expression of miRNAs has been to be regulated by the androgen receptor (AR), which seems to play an interesting role in the tumorigenic process of breast cancer. We hypothesized that AR may control the behavior of breast cancer cells via modulating the expression of miRNAs. Using PCR arrays, we examined the differential exp...

Objective: The aim of the present study was to evaluate cardio metabolic risk factors in patients with non-functional adrenal adenoma.Materials and methods: We studied thirty newly diagnosed adrenal adenoma patients and 30 healthy participants. Fasting glucose, insulin, lipid, hormone profile were evaluated from each patient.Results: The frequency of diabetes mellitus and hypertension were statistically higher in adrenal adenoma gr...

Background: Subclinical hypothyroidism is a thyroid disease which encountered in practice, commonly. Thyroid hormones affect metabolic syndrome parameters including HDL cholesterol, triglycerides, plasma glucose levels, blood pressure and abdominal obesity. Furthermore; there have been growing evidences about the relationship between vitamin D deficiency and autoimmune thyroid diseases. Therefore; we aimed to evaluate the association between the metabolic parameters and 25-OH-...

Aims: We aimed to determine the irisin level in patients with type 1 diabetes mellitus (T1DM) and to examine the relation of irisin level with inflammation and autoimmunity.Methods: This study included 35 cases diagnosed with T1DM and 36 healthy volunteers. Anti-glutamic acid decarboxylase (Anti-GAD), islet cell antibody (ICA), insulin autoantibody levels of the patients have been measured at the time they were included in the study and were recorded fro...

Introduction: The neuropathies are one of the most common complications seen in diabetes, affecting up to 50% of diabetic patients. Isolated or combined paralysis of 3rd, 4th and 6th cranial nerve can be seen.Case presentation: Sixty-six-year-old male patient was admitted to the neurology department with the complaints of diplopia persisting for 15 days. Cranial images revealed no abnormal findings. Patient was directed to internal medicine clinic due to...

Aim: In our study we aimed to investigate neutrophil/lymphocyte (N/L) ratio, variations in leukocytes and leukocyte subtypes and relationship between N/L ratio and insulin resistance (IR) in obesity.Material and methods: In this study 250 obese patients data were scanned retrospectively and 96 patients that are convenient to inclusion criteria and has complete file information were included in the study. Forty healthy individual with similar age and sex ...

Introduction and aim: There are few side effects of cabergoline which is used for medical treatment of prolactinoma. For this reason, cabergoline is considered as first-line therapy of prolactinoma. However, chronic administration of high dose cabergoline in patients with prolactinoma may be associated with valvular heart disease. The aim of this study is to evaluate left ventricular systolic and diastolic functions by conventional and tissue Doppler echocardiography in patien...

Introduction and aim: The metabolic changes of lipid profiles in prolactinoma treated with cabergoline are not completely clarified. The aim of this preliminary study is to evaluate changes of lipid profile in both of patients with functional hyperprolactinemia and prolactinoma before and after cabergoline treatment.Materials and methods: Twelve patients with prolactinoma who were treated with cabergoline (mean age 33.8±7.6 years and body mass index...